Membrane alterations induced by nonstructural proteins of human norovirus

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Membrane alterations induced by nonstructural proteins of human norovirus

Human noroviruses (huNoV) are the most frequent cause of non-bacterial acute gastroenteritis worldwide, particularly genogroup II genotype 4 (GII.4) variants. The viral nonstructural (NS) proteins encoded by the ORF1 polyprotein induce vesical clusters harboring the viral replication sites. Little is known so far about the ultrastructure of these replication organelles or the contribution of in...

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ژورنال

عنوان ژورنال: PLOS Pathogens

سال: 2017

ISSN: 1553-7374

DOI: 10.1371/journal.ppat.1006705